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Night Fix Enzyme Treatment

A treatment that repairs skin overnight to give you the radiant, healthier-looking skin associated with a good night’s sleep.


What it does:

Repair skin overnight to visibly minimize fine lines, boost hydration and revive radiance. This chronopeptide and tri-enzyme treatment, in sync with the body’s circadian rhythm, supports natural repair for renewed skin vibrancy. Encapsulated aroma technology prepares the senses for deep, restful sleep for healthier-looking skin by morning.


The morning after, clients agree that:

  • Skin looks refreshed, awakened, more hydrated and well-rested

After 1 week:

  • Skin looks more vibrant, smooth and has an improved texture

After 4 weeks:

  • Skin looks refreshed, awakened and illuminated

What else you need to know:

Which skin type is it good for?

  • Normal
  • Oily
  • Combination
  • Dry
  • Sensitive

Formulated without:

  • Parabens
  • Sulfates
  • Phthalates
  • Gluten
  • Alcohol
  • Synthetic colors
  • GMOs
  • Triclosan
  • Soy or soy derivative

Night Fix Enzyme Treatment is rated 4.6 out of 5 by 50.
Rated 5 out of 5 by from Truly brilliant! Given this product at Christmas. Skin glowing and being told how well I look and friends saying my skin looking great in particular. Fabulous!
Date published: 2020-01-09
Rated 5 out of 5 by from Amazing product Look of product: It comes in a great packaging, lovely bottle, with easy to apply pump ... How to apply: i applied this cream on night time after cleansing and moisturiser. This is non-greasy and absorbs into skin so nicely.it smells very nice  Affects on my skin:  i have dry combination skin with dry patches around lower part of my cheeks especially.  i started using it about 10 days ago , missed 2 nights..  The results are amazing.  As I have sleepless nights with my 3 kids ,  so my skin was really dehydrated, looked tired .  But now skin looks much healthier, younger, brighter and hydrated plus The dry patches improved a lot .   ANOTHER AMAZING FEATURE: Another great change I noticed is sleep improvement I used to wake up all night so many times even the wind blowing sounds wakes me up.. but after using this cream and following Dr Murad’s steps to apply it before bed,  it really improved my sleep   Nighttime ritual for better rest and better skin: Place Night Fix Enzyme Treatment on your nightstand or near your bed so you can smooth over skin just before lying downSmooth Night Fix Enzyme Treatment over face, then cup your hands loosely over your noseTake a deep breath through the nose and down into your belly, counting to three during the processHold your breath for 1 second, then release through the mouth, counting again to 3Repeat 3 times I got compliments on Eid from friends that My skin looks fresh radiant , beautiful and young...  Recommend the product:I definitely recommend this product to all the people who have dehydrated tired skin with bad sleep to give this product a try, it is not gonna disappoint anyone
Date published: 2019-09-03
Rated 5 out of 5 by from Super hydrating Love how this makes my skin feel at night, wake up with really hydrated face
Date published: 2019-05-22
Rated 4 out of 5 by from Super absorbent, noticeable difference! Having used this product for a month now I can say that there is a noticeable difference to my skin. This is now the third murad product I have used and I am amazed at how fantastic all their products are. This cream is super absorbent and smells wonderful. My skin feels more hydrated the morning after & I look forward to reapplying again. Always so nervous normally trying new products especially on my face however I trust murad products. Would highly recommend this for anyone who has tired oily skin looking for a healthy plump boost
Date published: 2019-03-26
Rated 5 out of 5 by from WOW! I can't believe how amazing this product is. I usually have a very dry flaky forehead and my skin is usually dehydrated. Within a couple of days I saw a massive difference when using the product. My skin felt soft, my forehead was no longer flaking or dry and my face felt amazing. It's not sticky and the scent made me feel relaxed.
Date published: 2019-03-26
Rated 3 out of 5 by from I hadn’t used a product like this before so it was interesting to try something new. The product smells really nice and when you put it on it makes your skin feel fresh and is very soothing. I saw small changes after two weeks of use; my skin does look slightly brighter and healthier than before using it but I haven’t seen any significant change to linesor wrinkles. I do think I will continue to see improvements if used over a longer period of time as part of a good ski routine.
Date published: 2019-03-25
Rated 5 out of 5 by from Wow I’ve been using this for a few weeks and I love it, my skin usually brakes out when I try a new product but not with this!!! The texture is amazing I’m so Impressed with how my skin felt after the first few days, my skin is positively glowing I will definitely buy more and I’m excited to try out more products in their murad range
Date published: 2019-03-25
Rated 4 out of 5 by from Luxurious cream This product delivers what it's says on the packaging! Very hydrating! The bottle will last ages as you only require a small amount for your face. Feels light on the skin which is good. Iv only used it every 2nd day as it is quite intense! Overall happy with this product.
Date published: 2019-03-25
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Solution for:

  • Lines and wrinkles
  • Dryness and dehydration
  • Dullness and loss of radiance
  • Rough texture

This product is:

  • Cruelty-free
  • Clinically tested by an independent laboratory and proven safe for sensitive skin

Did you know:

Skin loses water 3x faster at night.* Ingredients found in Night Fix Enzyme Treatment can help skin hold more water, and can help prevent overnight skin dehydration and support natural repair.

Dr.'s inspiration:

“Our body gets set to rest when the sun goes down, but our time-compressed schedules don’t align. Sleep is the first thing we sacrifice from our schedule as daytime responsibilities stretch well into the night. And it shows upon waking as dark under-eye circles, dullness, dehydration, deep-set wrinkles and puffiness. I created Night Fix Enzyme Treatment to encourage overnight skin repair through ingredients inspired by the science of sleep. Night Fix Enzyme Treatment is skincare that doubles as self-care, and is an essential part of a nightly routine that can help you rest better to rise and glow.”—Howard Murad, M.D., FAAD

*Results based on an average of 16 subjects.

How To Use

To use: PM

  1. After applying moisturizer, massage evenly over face and neck as the last step of your night-time regimen.
  2. Warning: Avoid contact with eyes.

Night-time ritual for better rest and better skin:

  • Place Night Fix Enzyme Treatment on your nightstand or near your bed so you can smooth over skin just before lying down
  • Smooth Night Fix Enzyme Treatment over face, then cup your hands loosely over your nose
  • Take a deep breath through the nose and down into your belly, counting to three during the process
  • Hold your breath for 1 second, then release through the mouth, counting again to 3
  • Repeat 3 times

Use with:


Ingredient spotlight:

Patent-pending aroma technology

Shown in clinical trials to enhance sleep quality. Goes beyond traditional aromatherapy as a functional fragrance that marries the science of sleep with the power of scent.


An anti-aging peptide, in sync the body’s circadian rhythm, supports natural repair for renewed skin vibrancy.

Tri-enzyme technology

Purified from red and green micro-algae. Three encapsulated enzymes provide potent antioxidant protection and detoxification to reduce visible signs of premature aging (loss of elasticity, lines and wrinkles).

Fragrance notes and benefits:

Lemon: Purifies and cleanses. Helps lift the day’s tension to invite happiness and positive energy.

Violet: Delicate, soothing; brings comfort to the mind.

Cedarwood: Earthy aroma. Helps elevate mood to calm the mind, relax and overcome stress.


Water/Aqua/Eau, Dimethicone, Glycerin, Propanediol, Niacinamide, Polymethylsilsesquioxane/Silica Crosspolymer, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Isononyl Isononanoate, Chlorella Vulgaris Extract, Haematococcus Pluvialis Extract, Glutamylamidoethyl Imidazole, Cucumis Sativus (Cucumber) Fruit Extract, Hordeum Vulgare (Barley) Extract, Helianthus Annus (Sunflower) Seed Extract, Tocopheryl Acetate, Sodium Hyaluronate, Butyrospermum Parkii (Shea) Butter, Urea, Yeast Amino Acids, Trehalose, Inositol, Taurine, Betaine, Sorbic Acid, Lecithin, Mannitol, Polysilicone-11, Ethylhexyl Isononanoate, PEG-7 Trimethylolpropane Coconut Ether, Polyglyceryl-10 Dioleate, Polyglyceryl-10 Dipalmitate, Propylene Glycol Dicaprate, Hexylene Glycol, Butylene Glycol, Caprylyl Glycol, Decyl Glucoside, Polyisobutene, Disodium EDTA, Ethylhexylglycerin, Phenoxyethanol, Fragrance (Parfum), Benzyl Salicylate, Citronellol, Geraniol, Hexyl Cinnamal, Linalool, Mica, Tin Oxide, Titanium Dioxide (CI 77891)